This article is from PLoS ONE, volume 9.AbstractProinflammatory high-density lipoprotein (p-HDL) is a biomarker of cardiovascular disease. Sickle cell disease (SCD) is characterized by chronic states of oxidative stress that many consider to play a role in forming p-HDL. To measure p-HDL, apolipoprotein (apo) B containing lipoproteins are precipitated. Supernatant HDL is incubated with an oxidant/LDL or an oxidant alone and rates of HDL oxidation monitored with dichlorofluorescein (DCFH).... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946658
byRymaszewski, Amy L.; Tate, Everett; Yimbesalu, Joannes P.; Gelman, Andrew E.; Jarzembowski, Jason A.; Zhang, Hao; Pritchard, Kirkwood A.; Vikis, Haris G.
This article is from Cancers, volume 6.AbstractChronic inflammation plays a key tumor-promoting role in lung cancer. Our previous studies in mice demonstrated that neutrophils are critical mediators of tumor promotion in methylcholanthrene (MCA)-initiated, butylated hydroxytoluene (BHT)-promoted lung carcinogenesis. In the present study we investigated the role of neutrophil myeloperoxidase (MPO) activity in this inflammation promoted model. Increased levels of MPO protein and activity were... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074819
This article is from Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, volume 2.AbstractBackground: We reported previously that Brown Norway (BN) rats are more resistant to myocardial ischemia/reperfusion (I/R) injury than are Dahl S (SS) rats. To identify the unique genes differentially expressed in the hearts of these rats, we used DNA microarray analysis and observed that enoyl coenzyme A hydratase–containing domain 2 (ECHDC2) is highly expressed... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835224
byMeyer, T; Kirkwood, A; Roughton, M; Beare, S; Tsochatzis, E; Yu, D; Davies, N; Williams, E; Pereira, S P; Hochhauser, D; Mayer, A; Gillmore, R; O'Beirne, J; Patch, D; Burroughs, A K
This article is from British Journal of Cancer, volume 108.AbstractBackground:: Transarterial chemoembolisation (TACE) has not been shown to be superior to bland embolisation (TAE) for treatment of hepatocellular carcinoma (HCC). Methods:: We conducted a randomised phase II/III trial in patients with untreated HCC. Patients were randomised to TAE with polyvinyl alcohol (PVA) particles alone or sequential TACE (sTACE) in which cisplatin 50 mg was administered intrarterially 4–6 h before... Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619271